GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs589756 | 1 | rs672343 | chr6:132635391 | MOXD1 | chr6:132617195-132722664:- | 0.27 | 4.69 | 3.52E-6 | Obesity-related traits |
| THCA | cis | rs7582720 | 1 | rs6723704 | chr2:203738664 | ALS2CR8 | chr2:203776978-203851060:+ | -0.29 | -5.93 | 5.93E-9 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs7582720 | 1 | rs6723704 | chr2:203738664 | ICA1L | chr2:203637873-203736371:- | 0.25 | 4.18 | 3.49E-5 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs3820928 | 1 | rs6723774 | chr2:227770592 | COL4A4 | chr2:227867435-228029275:- | -0.15 | -3.85 | 0.000135 | Pulmonary function |
| THCA | cis | rs11976180 | 1 | rs67239267 | chr7:143745116 | ARHGEF35 | chr7:143883677-143892736:- | -0.52 | -10.76 | 2.43E-24 | Obesity-related traits |
| THCA | cis | rs11976180 | 1 | rs67239267 | chr7:143745116 | OR2A1 | chr7:144015236-144016148:+;chr7 | -0.19 | -4.14 | 4.12E-5 | Obesity-related traits |
| THCA | cis | rs11976180 | 1 | rs67239267 | chr7:143745116 | OR2A9P | chr7:143991573-143997832:+;chr7 | -0.31 | -6.76 | 4.08E-11 | Obesity-related traits |
| THCA | cis | rs2241437 | 1 | rs6724025 | chr2:86200835 | LOC90784 | chr2:86247339-86250991:- | -0.43 | -4.74 | 2.82E-6 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs9677476 | 1 | rs6724253 | chr2:232121998 | ARMC9 | chr2:232063342-232238606:+ | 0.44 | 10.58 | 1.18E-23 | Food antigen IgG levels |
| THCA | cis | rs6748734 | 1 | rs6724662 | chr2:241831560 | C2orf54 | chr2:241825466-241835573:- | 0.29 | 6.38 | 4.1E-10 | Urinary metabolites |
| THCA | cis | rs9309473 | 1 | rs6724782 | chr2:73679990 | ALMS1P | chr2:73872046-73912692:+ | 0.69 | 11 | 2.99E-25 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6724782 | chr2:73679990 | NAT8 | chr2:73867850-73869537:- | 0.37 | 5.87 | 8.35E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6724782 | chr2:73679990 | TPRKB | chr2:73956957-73964517:- | -0.17 | -4.23 | 2.82E-5 | Metabolite levels |
| THCA | cis | rs67257959 | 1 | rs67257959 | chr19:17158145 | EPS15L1 | chr19:16466061-16582762:- | -0.2 | -3.54 | 0.000432 | Selective IgA deficiency |
| THCA | cis | rs67257959 | 1 | rs67257959 | chr19:17158145 | HAUS8 | chr19:17160573-17186343:- | -0.15 | -4.29 | 2.12E-5 | Selective IgA deficiency |